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Anthelminthic Agents of Mebendazole

  • Author:Ray Dean
  • Source:www.oceanchinachem.com
  • Release on :2017-02-21

Mebendazole is a broad-spectrum anthelmintics, in vivo or in vitro tests have been able to directly inhibit nematode glucose intake, leading to glycogen depletion, so that it can not survive, with significant kill larvae, inhibit the development of eggs , But does not affect the body's blood sugar levels. Can be used to control hookworm, roundworm, pinworm, whipworm, dung cynomolgus and other intestinal parasites.



Mebendazole is also a derivative of benzimidazole, which has a strong affinity for the beta-tubulin of the parasite and binds it at very low concentrations to inhibit the polymerization of microtubules, Or the disappearance of intestinal cells, reduce digestion and reduce the absorption of nutrients such as glucose, leading to the death of parasites. The drug can also inhibit mitochondrial elongation of fumaric acid reductase, reduce the transport of glucose, and oxidative phosphorylation coupling, thus affecting the production of ATP. The drug on the adult and eggs have a role.

 

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