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Atypical Antipsychotics of Quetiapine Fumarate

  • Author:Ray Dean
  • Source:www.oceanchinachem
  • Release on :2016-05-12

Quetiapine fumarate is a non-classical antipsychotic drugs, a variety of neurotransmitter receptor interactions. In the brain, quetiapine on serotonin (5HT2) receptor with high affinity for dopamine in the brain and greater than D1 and D2 dopamine receptor affinity. Quetiapine histamine receptors and adrenergic α1 receptors also have high affinity for adrenergic α2 low affinity receptor, but cholinergic receptors or drug benzodiazepine receptor substantially no affinity.

Quetiapine tablets do not have a lasting prolactin elevation phenomenon. In a multiple dose clinical trial found no differences in prolactin levels arising from different doses of quetiapine group, and no difference between the placebo group. Clinical trials showed that quetiapine tablets for the treatment of positive and negative symptoms of schizophrenia are valid. One with chlorpromazine, haloperidol and two controlled trials showed that quetiapine tablets fairly short-term efficacy of the control drug.

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