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Clinical Research of Loxoprofen

  • Author:Hubei Ocean Biotech Co.,LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-04-20

  Analgesic effect

(1) According to Randall - Selitto los SuoLuoFen sodium method (inflammation of the foot pressure method: the rat oral) the ED50 test value of 0.13 mg/kg, and contrast the ketone of ibuprofen, naproxen, indomethacin, compared with 10 ~ 20 times show strong analgesic action.

(2) Hot inflammatory pain rat method (oral) of rats experiment, los SuoLuoFen sodium ID50 value of 0.76 mg/kg, display and naproxen equally, ketone of ibuprofen and indomethacin 3-5 times more.

(3) Method of chronic arthritis pain (oral) of rats experiment, sodium SuoLuoFen of 50 value is 0.53 mg/kg, showed the strongest analgesic action, ketone of indomethacin, ibuprofen and naproxen four to six times.

(4) the analgesic action of peripheral agent.

 

Understanding

 Loxoprofen has the anti-inflammatory, antipyretic and analgesic action of PG synthetase inhibitors. Oral absorption quickly and completely, one drug plasma concentration of 2 ~ 4 hours after peak, more than 99% in the blood and plasma protein binding, t1/2 to 13 to 14 hours. About 95% since the discharge in prototype and metabolites in the urine. For rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout and motor system (such as joints, muscles and tendons) of chronic degenerative diseases and mild and moderate pain such as dysmenorrhea, all have certain curative effect. Medium degree of pain can be relieved by 1 hour after taking the drug, analgesic action 7 hours. For the curative effect of rheumatoid arthritis and osteoarthritis, similar to aspirin. For anemia, diseases of the gastrointestinal system or other reasons can not tolerate aspirin, indomethacin, anti-inflammatory analgesic patients, this drug can often get satisfactory effect.

Can safely and cortical hormone share, but share with cortical hormone, curative effect is not better than when corticosteroids alone. The goods with salicylic acid kind medicines salicylic acid class alone is no better than good. In addition, aspirin can accelerate the discharge of the goods.

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