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Clinical Use of Lamivudine

  • Author:Hubei Ocean Biotech Co.,LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-04-18

Lamivudine as antiviral drugs, used in the treatment of liver disease caused by hepatitis b virus infection.

Lamivudine English name for Lamivudine, chemical called 2 '3' - the DNA - 3 - thio 'cytosine (2' - 3 'deoxy - 3' - thiocytidine), also called 3 - TC. After China's listed commodity called he puding. Randomized controlled clinical trials at home and abroad show that the daily oral 100 mg can obviously inhibit HBV DNA levels, HBeAg seroconversion conversion rate increased with the extension of treatment time, for the treatment of HBeAg positive patients after 1, 2, 3, 4, and 5 years HBeAg serum conversion rate were 22%, 29%, 40%, 47% and 50% [1-3]. ALT level before treatment is the most high, generally HBeAg serological conversion rate is higher also [56-60]. Long-term treatment can reduce inflammation, reduce the incidence of liver fibrosis and cirrhosis [1, 2]. Randomized controlled clinical trials showed that this drug can reduce decompensated liver function and the incidence of HCC (hepatocellular carcinoma) [21]. In patients with decompensated liver cirrhosis can improve liver function, prolong the survival period (61-63). Study abroad, according to the results of lamivudine treatment the curative effect of chronic hepatitis b in children and adults are similar, good security,65 [64].

Liver transplantation for hepatitis b patients, before transplantation with lamivudine. After transplantation, lamivudine and HBIG combination, can obviously reduce HBV reinfection after liver transplantation, and can reduce HBIG dose.

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