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Drug Interaction of Pravastatin

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-06-01

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[Drug Interaction of Pravastatin]

Taking exams to enamine one hour before or after four hours to give this product or taking tests for mooring and standard one hour before meals to give this product, its bioavailability and therapeutic effect in clinic, have no obvious drop, at the same time, the bioavailability of this product is reduced 40% - 50%. And antipyrine joint application, it doesn't change the cytochrome P450 system of antipyrine cleared, because this product not induce hepatic drug metabolic enzymes, so not with other metabolic drugs by cytochrome P450 system (e.g., phenytoin sodium, quinidine) have obvious interaction.

 

This product is A 3 - hydroxy 3 - methyl glutaric acyl coenzyme A reductase (HMG COA reductase) competitive inhibitor, HMG COA reductase - is the speed limit of initial stage of cholesterol biosynthesis enzyme. This product is reversible to inhibit HMG COA reductase, thus inhibiting cholesterol biosynthesis. This product play a role of the lipid from two aspects, the first is through the reversible inhibition of HMG - COA reductase activity makes the amount of cholesterol in the cell has a certain degree of lower, led to the cell surface increases with low density lipoprotein (LDL) receptor, thus strengthening the mediated by receptors.