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Esomeprazole sodium

  • Author:Hubei Ocean Biotech Co,.LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-05-10
Clinical application of Esomeprazole sodium
(1) for the treatment of gastroesophageal reflux disease, reflux esophagitis and (or) with severe reflux symptoms. Intravenous esomeprazole make erosive esophagitis cure rate of 80%, when GERD patients have difficulty swallowing, vomiting, bleeding and other complications, intravenous esomeprazole quickly and effectively inhibition of gastric acid secretion, to maintain the long intragastric pH> 4, so as to achieve a good therapeutic effect.
(2) for the treatment of upper gastrointestinal bleeding gastrointestinal bleeding non-variceal upper, usually first in endoscopic hemostasis, rapid hemostasis after application of drugs to increase gastric pH above 6, in order to promote the prevention of platelet aggregation and thrombolysis, prevent rebleeding. Can rapidly improve the currently accepted intragastric pH> 6 above, to the immediate intravenous omeprazole 80 mg, followed by 8 mg / h intravenous infusion to maintain the acid-suppressing effect is more ideal. Acid-suppressing effect of esomeprazole and omeprazole is superior to last longer, no doubt, for the treatment of acute upper gastrointestinal bleeding will be more effective and convenient.
(3) stress ulcer gastric pH change is closely related to gastric mucosal lesions, such as effective control of gastric acid secretion and intragastric acidity, to some extent you can control and cure the pathological changes of gastric mucosa during stress. Existing studies show that intravenous omeprazole can quickly increase gastric pH, effective treatment of stress ulcer. Because esomeprazole maintained intragastric pH> 4 for longer, I believe for the treatment of stress ulcer effect is more significant.
In short, a new generation of injection PPI esomeprazole sodium due to the unique pharmacokinetic characteristics of its acid-suppressing ability than oral esomeprazole and other injection PPI faster and more efficiently. For patients with clinical need but can not use the PPI for oral administration, such as gastrointestinal bleeding and stress ulcer, injectable esomeprazole provides potent acid-suppressing acute and comprehensive protection.

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