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History of Isonicotinic

  • Author:Hubei Ocean Biotech Co.,LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-04-18

In 1912, Isonicotinic was originally by Charles university, Prague (Germany), a graduate student of chemistry mayer (Hans Meyer) and Murray (Josef Mally) do doctoral thesis in 1912. They don't realize that their products fully the great medicinal value. In forgotten about 40 years later, the United States rose and bristol-myers squibb company and researchers in west Germany's bayer respectively independently discovered Isonicotinic strong antimycobacterial activity.

In 1951, the clinical trials of Isonicotinic in New York in 1951.

In 1952, Isonicotinic first listed in the U.S. by roche, rimifon commodity name.

After years of use, it was found that Isonicotinic bactericidal power, high selectivity, less side effects. Especially its cheap, may be some people in the poor areas to afford. Isonicotinic sterilization characteristic is that it can inhibit the synthesis of n/med tuberculosis bacterium bacterium wall branch bacterium acid ingredients, so that the loss of a variety of n/med tuberculosis bacili ability (acid dyeing, proliferation, hydrophobic) and death, Isonicotinic also can combine with TB bacteria coenzyme, interfering with the role of DNA and RNA synthesis, so as to achieve the purpose of kill n/med tuberculosis bacterium. The study also found that Isonicotinic stronger effect on metabolism of n/med tuberculosis bacterium.