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Introduction of Ketoprofen

  • Author:Hubei Ocean Biotech Co.,LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-06-12

Ketoprofen  is white crystalline powder; Odourless or almost odourless. Easily soluble in methanol, easily dissolved in ethanol, acetone or ethyl ether, almost insoluble in water. Melting point of about 93-96 ℃. For the aryl alkyl acid compounds. Have analgesic, anti-inflammatory and antipyretic effect. Ibuprofen for strong anti-inflammatory effect, side effect is small, low toxicity. Oral from the gastrointestinal tract can absorb. Once, after the treatment about o. 5 ~ 2 hours can reach peak plasma concentration. T 1/2 is 1.6 ~ 1.6 hours. In the blood and plasma protein binding force strong. Within 24 hours since the urine discharge at a rate of 30% 90%. Mainly glucuronic acid combination form. Used in rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, joint strong hard spondylitis, gout, etc.

Drug Interaction:

(1) alcohol and used in conjunction with other non-steroidal anti-inflammatory drugs , can increase the gastrointestinal side effects, also has caused the risk of ulcer.

(2)Acid with aspirin or other drugs with unavailable, not increase curative effect, and gastrointestinal side effects and an increased incidence of bleeding tendency.

(3) to be Shared with anticoagulants, increases the risk of bleeding.

(4) Ketoprofen can strengthen the diabetes drug resistance; Reduce the antihypertensive effect of antihypertensive drugs; Shared with corticosteroids, can significantly slow the symptoms of inflammation.

(5) should not be Shared with methotrexate, in case of poisoning.

(6) with probenecid and verapamil, nifedipine, attention should be paid to reduce the dose; Available with Digoxin, pay attention to adjust doses of Digoxin.


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