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Medical Function Of Bifonazole

  • Author:Ray Dean
  • Source:www.oceanchinachem,com
  • Release on :2016-06-05

Bifonazole, as a broad-spectrum anti-fungal drugs, which formulations are creams, gels, suppositories and the like. For the treatment of superficial fungal skin infections, such as: hand, foot and ringworm, body, jock itch, tinea versicolor, skin candidiasis. The drug is an imidazole antifungal agent with broad-spectrum anti-fungal effect on the skin fungi, yeasts, molds and other fungi, such as mold M. furfur, Corynebacterium tiny valid. In vitro tests showed that effects of this drug on the skin fungus (such as Trichophyton) mainly sterilization, and the effect of yeast is mainly bacteriostatic.

 

According to the literature normal adult abdominal skin 10 × 20cm 0.1g bifonazole applied using gas chromatography - mass spectrometry method for determination of plasma concentration, time to peak (Tmax) was 12 hours after administration, peak plasma concentration ( cmax) was 3.8ng / ml, skin absorption rate is very low. Local rabbit skin (10 × 20cm) coated with 0.1g of bifonazole, the plasma peak time (Tmax) was 3 hours after administration, peak plasma concentration (Cmax) was 140ng / ml, and 24 hours is still certain concentration (100ng / ml). Extravascular administration with an open two-compartment model kinetic parameters obtained by processing instructions transfer speed central chamber and the peripheral chamber is substantially the same, suggesting that bifonazole in the organization reserving scarce.

 

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