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Medical Function Of Capecitabine

  • Author:Ray Dean
  • Source:www.oceanchinachem,com
  • Release on :2016-05-29

Capecitabine is a kind that can be converted in vivo to 5-FU antimetabolite fluoropyrimidine carbamate deoxynucleoside drug developed by Roche, trade name Xeloda, capable of inhibiting cell division and interfere with RNA and proteins (protein) synthesis. Suitable for further treatment including paclitaxel and anthracycline chemotherapy ineffective advanced primary or metastatic breast cancer. Mainly used for advanced primary or metastatic breast cancer, colorectal cancer, colon cancer, and treatment of gastric cancer.

 

Normal cells and tumor cells to 5-FU can be metabolized to 5-fluoro-2-deoxy-uridine monophosphate (FdUMP) and 5-fluoro uridine triphosphate (FUTP). These two kinds of metabolites through cell damage caused by different mechanisms. First, FdUMP and folic acid cofactor N [sup] 5,10 [/ sup] - methylenetetrahydrofolate and thymidylate synthase (TS) to form covalently bound triplicate thereof. This binding inhibition 2'-deoxyuridine [pyrimidine core] nucleotide formation of thymidylate. Thymidylate thymine triphosphate precursors necessary, which is required for DNA synthesis, and therefore less of the compound can inhibit cell division.

 

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