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Medical Usages of Amikacin Sulfate

  • Author:Ray Dean
  • Source:www.oceanchinachem.com
  • Release on :2016-11-21

Amikacin sulfate is an aminoglycoside antibiotic. This product on the majority of Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Enterobacter, Proteus, Shigella, Salmonella, Citrobacter, Serratia and so on Has a good effect on Pseudomonas aeruginosa and other Pseudomonas, Acinetobacter, Alcaligenes, etc. also have a good effect; Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Mycobacterium, Campylobacter, Mycobacterium tuberculosis and some non-tuberculous mycobacterium also has good antibacterial activity, its antibacterial activity slightly lower than gentamicin. This product is the most prominent advantage of many intestinal Gram-negative bacilli produced by the aminoglycoside passivation enzyme stability, will not passivation of such enzymes lose antibacterial activity.

 

In the current isolation of the 12 passivation enzyme, the goods can only be AAC (6 ') passivation, in addition to AAD (4') and APH (3 ') - even can cause bacteria on the moderate Resistant. Clinical isolates of Enterobacteriaceae bacteria gentamicin, tobramycin and netilmicin and other aminoglycoside resistance of about 60% to 70% of the goods are still sensitive. In recent years gram-negative bacilli in the amikacin-resistant strains have increased.

 

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