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Medical Usages of Mildronate

  • Author:Ray Dean
  • Source:www.oceanchinachem.com
  • Release on :2016-11-15

Mildronate is a novel cardiotropic drug that acts on mitochondria to improve myocardial energy metabolism at the cellular level. Mildronate is a structural analogue of carnitine, which can inhibit betaine hydroxylase, thereby inhibiting the biosynthesis of carnitine and directly inhibiting the transport of carnitine-dependent fatty acids in mitochondria. Inhibition of carnitine biosynthesis can reduce the concentration of intracellular free carnitine, to prevent isoproterenol-induced acylcarnitine accumulation.

 

Mildronate can reduce the accumulation of long-chain acylcarnitine, which can inhibit carnitine-dependent fatty acid oxidation, so that the energy metabolism of hypoxic myocardium from fatty acid oxidation into a more favorable glucose oxidation, that is to promote the glycolysis pathway Anaerobic oxidation, so the product has anti-hypoxic effect and cardiac protective activity. In addition, mydrazine can inhibit carnitine acetyltransferase, it can increase mitochondria metabolic pathway of acetyl CoA utilization, to prevent the decline in ATP and ADP concentration, and to prevent isoproterenol-induced AMP accumulation and To reduce the energy charge, play a role in myocardial protection.

 

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