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Oncotarget: Vitamin C anticancer effect was actually ten times that of some anticancer drugs!

  • Author:DOI:10.18632/oncotarget.15400
  • Release on :2017-03-16


According to the World Health Organization (WHO), cancer has become the second leading cause of death and pain in the world. In 2015, nearly 9 million people worldwide died of cancer. At the same time, the relevant practitioners predicted that in the next 20 years, a variety of new cases of cancer will grow by about 70%. The National Cancer Institute (NCI) estimates that almost 40% of US men and women will develop cancer at some point in their lives.

At the same time, although a variety of treatment methods can be used for the treatment of cancer, but the vast majority of these treatment techniques are not absolutely effective. In addition to the difficult to protect the efficacy of the majority of cancer treatment because of its own toxicity and damage to the patient's body and let most patients discouraged.

In some of the worst cases, the patient's cancer condition can not even be completely controlled by conventional treatment, cancer stem cell metastasis and division of the patient's cancer condition further deteriorated until the patient's life.

In a recent article published by Oncotarget, an internationally renowned journal oncology, the researchers introduced three natural substances, three experimental drugs, and a specific drug that is clinically used to inhibit the growth of tumor stem cells (CSCs).

The study was conducted by researchers from the University of Manchester, Salford, England, where the research team was led by Dr. Gloria Bonuccelli.

Through a series of experiments, these scientists were surprised to find that vitamin C actually showed a maximum of 10 times the efficacy of the experimental group of drugs.

The researchers tested the efficacy of a total of seven common tumor drugs and general drug tumor cells, including benzodiazoles for the synthesis of drugs such as vitamin B12, three drugs that have direct or adjuvant effects on cancer. (Actinonin), FK866, 2-DG and three natural substances, phenylephrine (CAPE), silibinin and ascorbic acid (vitamin C).

Researchers have focused attention on the energy supply system of tumor stem cells (CSCs). The energy supply of tumor stem cells directly determines the growth and division of this tumor stem cell, which directly affects the occurrence and metastasis of cancer. Dr. Bonuccelli and his colleagues hope to find drug molecules that specifically inhibit the supply of cancer stem cells to the system.

In several of the tested drugs, the researchers found that FK866 on tumor stem cell function mechanism of the most obvious inhibition. At the same time, the researchers also found that they selected three natural molecules on the tumor stem cell energy supply system has a certain inhibitory effect. In these natural molecules, especially vitamin C on the tumor stem cell energy supply system is particularly evident, vitamin C on the system's ability to suppress even up to 2-DG (2-deoxy-D-glucose, proved to be able to suppress more The growth of tumor cells).

In addition, the researchers also found that vitamin C on cancer stem cells within the glycolysis process to play a role in inhibiting. Glycolysis is essential for the supply of cellular energy and even cell division.

Dr. Michael P.Lisanti, a professor of transformation medicine at Salford University, Dr. Bonuccelli, commented, "I found a targeted drug for cancer stem cells, and we even tested the inclusion of milk thistle extract silibinin and bee isolate CAPE (Phenylephrine), but the most exciting thing about vitamin C, the use of this cheap and non - toxic and harmless drugs to treat cancer can be said to be a major advance in cancer treatment.

"Our study further confirms that several non-toxic drugs, including vitamin C, can inhibit the growth of tumor cells," the authors said.

"Our research has ensured the rationality of putting vitamin C into clinical research and provided a potential cure for the prevention of tumor recurrence and metastasis," Dr. Bonuccelli added.

Once upon a time, Nobel laureate Linus Pauling had suggested that vitamin C could serve as a potential non-toxic anti-cancer drug. The author of the article appears that it is their study that confirms the specific inhibition of vitamin C for the energy metabolism of tumor stem cells and confirms Pauling's words through experiments.