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Pharmaceutical Actions of Afatinib

  • Author:Ray Dean
  • Source:www.oceanchinachem.com
  • Release on :2016-10-20

Afatinib is an oral drug and is an irreversible inhibitor of epidermal growth factor receptor (EGFR) and human epidermal receptor 2 (HER2) tyrosine kinase. Phase IIb / III randomized studies have shown that compared with placebo plus best supportive care, patients who received the best supportive regimen of alfentanil versus non-small-cell lung cancer who had previously failed a second-line chemotherapy and failed EGFR-TKI therapy, Survival, but significantly improved progression-free survival, improved ORR and 8-week disease control rate. In another study (LUX-LUNG2), the majority of patients (61%) with common EGFR mutations showed a significant reduction in tumor size, delayed tumor progression, and longer survival after treatment with alfatinib. These results confirmed that alfentanil is a promising target drug.

 

It is the second generation of highly efficient dual irreversible tyrosine kinase inhibitors. Erlotinib and gefitinib as a tyrosine kinase inhibitor, EGFR alone inhibition, BIBW2992 while inhibiting EGFR and HER-2 receptors. James St, Gay Medical College, London, UK, and other patients with solid tumors were studied in a phase I clinical study showed EGFR mutations in patients with NSCLC can get encouraging results, 20% of patients with persistent PR (2 women and 1 male), of which 2 showed deletion of EGFR exon 19, which was more common in women, non-smokers and adenocarcinoma patients.

 

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