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Pharmacokinetic of Sodium Fusidate

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-05-11

   

         Sodium fusidate has excellent tissue penetration, widely distributed in the body. Clinically is particularly important, this product not only has a high concentration in the blood supply is rich in organization. Even in the blood vessels distribution in organization also has a less concentrated. Known in pus, sputum, soft tissue, heart, bone tissue, synovial fluid, and death of bone scab, brain abscess, burns and intraocular, west to the concentration of sodium fusidate than its minimum bacteriostatic concentration of staphylococcus aureus (0.03-0.16 micrograms/ml). Sildenafil acid sodium in the liver metabolism, is mainly composed of bile discharge, almost without renal excretion.

         Sodium fusidate is extremely low, and other clinical use of antimicrobial agents, no cross between allergic and therefore can be used for the treatment of patients to other antibiotics taboos, such as allergic to penicillin and other antibiotics. For serious or deep infection and when to use for a long time, suggest, west acid sodium and other resistant staphylococcus drug combination in order to reduce the development of drug resistance. , west to sodium with resistance to penicillin enzyme of penicillins, cephalosporins, erythromycin, aminoglycoside, clindamycin, rifampin and vancomycin combination, and add or synergy effect can be obtained.

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