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Pharmacological Action of Amphotericin B

  • Author:Ray Dean
  • Source:www.oceanchinachem.com
  • Release on :2016-05-30

Amphotericin B is separated from the culture broth of Streptomyces in a derived class of polyene antifungal agents. Yellow or orange-yellow powder; odorless or almost odorless, tasteless; have cited moist, easily damaged failure in daylight. In dimethyl sulfoxide was dissolved in dimethyl formamide, slightly soluble, very slightly soluble in methanol, insoluble in water, ethanol, chloroform or ether. In a neutral or acidic medium can form salts, water-soluble antimicrobial activity will increase but decrease, which do deoxycholic acid sodium injection. Polyene antibiotics is mainly used for deep fungal infections, such sterol antibiotics and fungal cells binding permeability membrane damage, resulting in fungal potassium ions, nucleotides, amino acids and other leakage, destruction of normal metabolism and antibacterial effect.

 

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