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Pharmacological Action of Aztreonam

  • Author:Hubei Ocean Biotech Co,.LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-06-02

Aztreonam is suitable for the treatment of sensitive aerobic gram-negative bacteria caused infections, such as: urinary tract infections, lower respiratory tract infections, sepsis, intra-abdominal infections, gynecological infections, surgical wounds and burns, ulcers, skin and soft tissue infections Wait. Aztreonam for most aerobic gram-negative bacteria with a high degree of antibacterial activity, including Escherichia coli, Klebsiella pneumoniae and Klebsiella bacteria Oak Esposito, aerogenes, Enterobacter cloacae, Proteus, sand Ray Enterobacteriaceae spp, citrate, Shigella spp, and Haemophilus influenzae, Neisseria gonorrhoeae, meningococcus.

 

Pseudomonas aeruginosa also has its good antibacterial activity, some Pseudomonas and antibacterial effect other than P. aeruginosa Acinetobacter for poor, Staphylococcus, Streptococcus, etc. aerobic and anaerobic gram-positive bacteria without antimicrobial activity. Aztreonam through sensitive aerobic gram-negative bacteria cell membrane penicillin-binding protein 3 (PBP3) high affinity and inhibit cell wall synthesis. Most of the β- lactam antibiotics except that it does not induce bacterial β- lactamase, most of the bacterial β- lactamases produced simultaneously highly stable.

 

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