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Pharmacological Action of Bacitracin

  • Author:Ray Dean
  • Source:www.oceanchinachem,com
  • Release on :2016-06-05

Bacitracin, C66H103N17O16S, white or light yellow powder; odorless, bitter taste; have cited moist; susceptible to oxidant damage, heavy metal salts in solution can be precipitated. This product is soluble in water, dissolved in ethanol, insoluble in acetone, chloroform or ether, antibacterial spectrum similar to penicillin, against Gram-positive bacteria and negative bacteria, Streptococcus pneumoniae, Staphylococcus aureus, Neisseria gonorrhoeae, meningococcus spirochetes and the like have a bactericidal effect. Its mechanism of action is not only to act on the cell wall, but also affect protoplasts, also on the cytoplasmic membrane damage effect, affecting its permeability. This product is toxic to the kidneys, clinical application is limited, generally do not make systemic administration, mainly used in clinical staphylococcal infections resistant to penicillin and externally to the skin infections.

 

Peptide antibiotic bacitracin genus of Gram-positive bacteria with a bactericidal effect, the main mechanism for the inactivation of the enzyme so that pyrophosphate, which specifically inhibits bacterial cell wall synthesis stage dephosphorylation, affecting the transport of phospholipids and the cell wall the stent delivery sticky peptide, thereby inhibiting cell wall synthesis. Bacitracin still sensitive bacteria with the cell membrane binding, damage cell membranes, resulting in a variety of ions, amino acids and other important material loss. Skin and soft tissue and eye for Staphylococcus aureus, hemolytic streptococcus, pneumococcus and other infections caused by susceptible strains. Due to severe renal toxicity of this product now without systemic administration, topical application only.

 

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