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Pharmacological Action of Bisoprolol Fumarate

  • Author:Ray Dean
  • Source:www.oceanchinachem,com
  • Release on :2016-06-10

Bisoprolol Fumarate the product β-blockers, bronchial and vascular smooth muscle β1- receptor with high affinity, so that blood vessels dilate, blood pressure is lowered. For hypertension, coronary heart disease, and moderate to severe chronic stable heart failure embolism.

 

Bisoprolol is a highly selective β1- adrenoceptor antagonists, no intrinsic sympathomimetic activity and membrane stabilizing activity. Bisoprolol bronchial and vascular smooth muscle β1- high affinity receptors on bronchial smooth muscle and blood vessels and regulate metabolism β2- only low affinity receptors. Therefore, bisoprolol is generally not affect the metabolic effects airway resistance and β2- receptor modulation. Bisoprolol still has a role in the receptor selectivity β1- beyond the therapeutic dose.

 

Bisoprolol is excreted from the body in two ways. 50% is then excreted from the kidneys, the remaining 50% is discharged in the form of the prototype drug from the kidneys metabolized by the liver to inactive metabolites. Because of the same drug from the kidneys and liver clearance ratio of mild to moderate liver and kidney dysfunction in patients do not require dose adjustment. For chronic stable heart failure with impaired liver function or in patients with renal insufficiency.

 

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