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Pharmacological Action of Rocuronium Bromide

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-06-07

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Pharmacological Action of Rocuronium Bromide:

 

The interaction between rocuronium is a non depolarizing neuromuscular blockers, structure similar to vecuronium and Pan Kanlang ning (pancuronium). And other non depolarizing drugs, it with competitive sports synaptic cholinergic receptors on nerve endings, the role of acetylcholine in antagonism. Depolarizing neuromuscular blockers succinyl choline (scoline) due to its effective fast, short action time and is widely used for endotracheal intubation, however, it will produce a large number of adverse reactions, and even have serious complications (e.g., malignant hyperthermia, arrhythmia caused by high potassium). Non depolarizing neuromuscular blocking agents safer than succinyl choline, but work is slow, effect time is long, there are shortcomings in some applications. The interaction between rocuronium effect fast, and there are dose dependent. In non depolarizing neuromuscular blocking agent, this product works fastest, generally after intravenous can offer excellent conditions for intubation in 60 seconds. This kind of working time and succinyl choline similar or slightly longer, but muscle rather than vecuronium, card (tracrium) and ammonium chloride m wow library (mivacron) 2 times faster. So when making rapid endotracheal intubation, this product can replace succinyl choline. However, short duration of succinyl choline (usually less than 10 min), and this product lasts at least 30 min, this is similar to vecuronium and muscle ning. Will this product ion penetration frog chest muscle can measure of its effect on neuromuscular endplate. This product of motor nerve terminals inhibition compared with other muscle relaxant, the product of motor nerve terminals inhibitory effect than d - chlorine cylinder curare and pancuronium bromide amine is weak, but is similar to d library bromine amine. Intravenous anaesthesia does not affect the product of the neuromuscular blocking effect, also does not affect the schedule.