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Pharmacological Action of Somatostatin

  • Author:Ray Dean
  • Source:www.oceanchinachem.com
  • Release on :2016-07-08

Somatostatin, for esophageal varices bleeding due to portal hypertension, peptic ulcer stress ulcer, erosive gastritis caused by the gastrointestinal bleeding, prevention and treatment of acute pancreatitis and its complications; pancreatic, bile, intestinal fistula adjuvant therapy.

 

 

Within healthy human-derived somatostatin concentration in the plasma is very low, generally in 175ng / L or less. After intravenous administration, somatostatin shows a very short plasma half-life, based on the results of immunoassays radioactivity, half-life is generally between about 1.1 to 3 minutes; for liver patients, the half-life of 1.2 to 4.8 minutes Room; chronic renal failure patients, the half-life of between about 2.6 to 4.9 minutes. Per hour 75 & micro; g speed after intravenous infusion of somatostatin, within 15 minutes of peak concentration 1250ng / L, metabolic clearance rate per minute 1L, the half-life of 2.7 minutes. Intravenous 2 & micro; g after 125 hormone somatostatin, and excreted in the urine of 40% after 4 hours, 24 hours after excretion by 70%. Somatostatin in the liver by cyclization of N- terminal portion and aminopeptidase enzyme and intramolecular cleavage of the peptide chain, the rapid metabolism in the liver.

 

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