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Pharmacological Action of Tranilast

  • Author:Ray Dean
  • Source:www.oceanchinachem.com
  • Release on :2016-07-29

Tranilast is an allergy medium-blockers, inhibit allergens and other stimuli cause mast cell degranulation and the release of allergy mediators reaction. Having a cell membrane stabilizing mast cells and basophils, preventing degranulation. Thereby inhibiting the release of histamine and serotonin substance of anaphylaxis, the IgE antibodies cause allergic skin reaction and experimental rats significantly inhibited asthma is an allergic disease pathogenesis for the cause of therapeutic drugs.

 

Except tranilast with other antihistamine that tranilast suppressed due to the treatment of allergic reactions, can effectively prevent the occurrence and development of allergic reactions. And antihistamines, corticosteroids compared to the side effects, allergic reactions significant effect.

1, TNL can inhibit mast cells and basophils phosphodiesterase that elevated levels of intracellular cyclic AMP, reduce free calcium into the cell, cell membrane stability, prevent degranulation and histamine release and other chemical media.

2, reduce serum IgE levels: The IgE binds to the antigen can mast cells to release histamine and serotonin and other chemicals. TNL is not only a mast cell stabilizer, is also likely to produce IgE plasma cell lines inhibited.

 

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