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Pharmacological Actions of Inosine Pranobex

  • Author:Hubei Ocean Biotech Co,.LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-04-14

1. Antiviral Effect

Inosine pranobex mainly through indirect improve antiviral host immune function, but can't rule out some direct effects. Function of T lymphocytes decreased during virus infection, Inosine pranobex immunosuppressive state restoration, inhibit viral RNA synthesis within infected cells, moreover can enhance the effect of interferon. Can inhibit DNA virus in cell culture (herpes simplex virus, adenovirus, vaccinia virus), RNA viruses (rhinovirus, influenza a and b viruses, polio, measles, mumps virus).

2. Immunomodulatory Effects

1Effects on immune function in vitro: lymphocytes of static effect, but can enhance the plant haemagglutinin or antigen triggered an immune response, promote the differentiation and proliferation of T lymphocytes, T lymphocytes of produce destruction. Can activate TH cells in vitro and can improve the function of T cells inhibit, therefore considered T cells of the regulator. Can increase production of lymphatic activin, enhance macrophage activity and the function of natural killer cells, improve the effect of interferon.

Effects on immune function in animals: with Inosine pranobex mice infected with influenza virus after treatment, increase the reaction of the spleen cell proliferation of influenza antigen 3 times, can be completely reversed immunosuppression caused by virus.

The role of human immune function: contact the influenza virus pathogenic volunteers, treatment with Inosine pranobex in 3 ~ 6 days, caused by a virus obviously increase the lymphocyte proliferation and lymph toxin of infected cells also increased significantly. Ⅰ type or Ⅱ herpes simplex virus infection patients after treatment with Inosine pranobex, peripheral lymphocytes in PHA induced by increased by 138%; Response to the antigen of herpes, lymphatic activate a 63% increase in the produce of grain and lymph toxin.

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