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Pharmacological Actions of Moxifloxacin Hydrochlorid

  • Author:Hubei Ocean Biotech Co.,LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-04-26

(1) The mechanism of action

       Moxifloxacin is broad spectrum and antibacterial activity of 8 - methoxy fluoroquinolone antibacterial drug. Moxifloxacin in vitro shows of gram-positive bacteria, gram-negative bacteria, anaerobic bacteria, acid bacteria, and atypical organisms such as mycoplasma, chlamydia and legionella bacteria have broad spectrum antimicrobial activity. Antibacterial mechanism for the interference Ⅱ, Ⅳ topoisomerase. DNA topoisomerase is control topology and key enzyme in DNA replication, repair, and transcription. The sterilization curve show that moxifloxacin is a concentration dependence of bactericidal activity. The minimal inhibitory concentrations (mic) and minimum bactericidal concentration are basically identical. Moxifloxacin on beta lactam class and large ring lactone class antibiotic resistant bacteria are effective. Through the experimental animal model of infection confirmed that moxifloxacin high activity in the body.

 

(2)Resistance


      Lead to penicillin and cephalosporin, sugar peptide, large ring lactone class and tetracycline resistance mechanism of drug resistance does not affect the antibacterial activity of moxifloxacin. Moxifloxacin and there is no cross resistance to these antimicrobials. Has not yet found the emergence of resistance plasmid mediated.

8 - methoxy part of moxifloxacin compared with 8 - hydrogen part has the drug resistance of gram positive bacteria highly active and low selectivity of mutation. Seven second nitrogen heterocyclic replace can prevent reactive flow, the activity of outflow for fluoroquinolone resistance mechanisms. In vitro experiments show through multi-step mutation can slow the emergence of drug resistance of moxifloxacin. In conclusion ni is very low (10-7-10-10). Sequence of the bacteria when exposed to lower than that of moxifloxacin MIC concentration can only make the MIC value has a small amount of increase. Other types of quinolone between cross resistance. However, some of other types of quinolone resistant gram-positive bacteria and anaerobic bacteria sensitive to moxifloxacin.

 

(3) The role of human intestinal flora


   By means of two volunteers after taking moxifloxacin research observed the following changes: escherichia coli, bacillus, ordinary bacteroides, enterococcus, white clay bacteria and anaerobic bacteria such as bifidobacteria, true bacillus and streptococcus, etc. These changes can be back to normal within two weeks, not found difficult clostridium toxins.

 

    Hubei Ocean Biotech Co., Ltd - China Pharmaceutical Raw Material Supplier is a professional chemical industry enterprise, integrating production and trade. We also a Acyclovir China API supplier has developed into a professional chemicals enterprise which meets different demands from global customers by years' pursuit and striving.