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Pharmacological Effects of Benzylpenicilline Benzathine

  • Author:Ray Dean
  • Source:www.oceanchinachem,com
  • Release on :2016-06-05

Benzylpenicilline Benzathine, its sodium, potassium salts are white crystalline powder; odorless or slight specific smell, have cited moist; case of acid, alkali or oxidizing agent that is rapid failure, solution stand at room temperature prone to failure. Highly soluble in water, soluble in ethanol, insoluble in fatty oils or liquid paraffin. Procaine penicillin (pr0caine benzylpenicillin) as a white microcrystalline powder; case of acid, reducing or oxidizing agents such as rapid failure. Soluble in methanol, ethanol or slightly soluble in chloroform, slightly soluble in water. Benzathine penicillin (benzathine benzylpenicillin) as a white crystalline powder. Penicillin free acid has a pKa of 2.8. Penicillin sodium 0.6μg as one unit, lmg equivalent to 1670 units. Penicillin potassium 0.625μg as one unit, lmg equivalent to 1598 units.

 

Bicillin extremely slow absorption, low plasma concentration for need long-term use of penicillin prophylaxis patients, such as patients with chronic rheumatic heart disease. In the period from bacteria bactericidal effect on Gram-positive cocci (Streptococcus pneumoniae, sensitive Staphylococcus aureus) and gram-negative bacteria (meningococcus, Neisseria gonorrhoeae) a strong antibacterial effect against gram-positive bacilli ( diphtheria), spirochetes (Treponema pallidum, relapsing fever spirochete, Leptospira), Clostridium (Clostridium tetani, gas gangrene bacillus), actinomycetes and some Bacteroides have an antibacterial effect. Penicillin sodium, potassium, not acid, poor oral absorption, not suitable for oral administration.

 

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