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Pharmacological function OF Dexamethasone

  • Author:Hubei Ocean Biotech Co,.LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-04-28
Dexamethasone also known as dexamethasone, fluorometholone strong ground, Desha dexamethasone, a glucocorticoid hormone. Its derivatives are pine hydrocortisone, prednisone, with its pharmacological effects are anti-inflammatory, anti-drug, anti-allergic, anti-rheumatic, more extensive clinical use. Easily absorbed from the digestive tract, the plasma T1 / 2 of 190 minutes, and tissue T1 / 2 to 3 days, respectively, in l hour and 8 hours of peak plasma concentration after intramuscular injection of dexamethasone sodium phosphate or dexamethasone acetate . The product is plasma protein binding rate than other corticosteroids to be low. The product 0.75mg anti-inflammatory activity equivalent to 5mg prednisolone. Adrenocorticotropic hormone drugs, anti-inflammatory, anti-allergic and anti-drug more effective than prednisone, sodium retention and promoting the removal of potassium is very light, can be intramuscular or intravenous pituitary - adrenal strong inhibition.
1. The anti-inflammatory effects: This product can reduce and prevent tissue response to inflammation, thereby reducing inflammation of the performance. Hormone suppression of inflammatory cells, including leukocytes and macrophages accumulation at sites of inflammation, and inhibition of phagocytosis, lysosomal enzyme release, and synthesis and release of chemical mediators of inflammation.
2. immunosuppressive effects: including the prevention or inhibition of cell-mediated immune response, delayed hypersensitivity reactions, reducing the T lymphocytes, monocytes, eosinophils number, reducing the binding capacity of immunoglobulin with cell surface receptors and inhibit the synthesis and release of interleukin, thereby reducing the T lymphocytes to lymphoblastoid cell transformation, and reduce the primary immune response to expansion. Reduces immune complexes through the basement membrane, and can reduce the concentration of complement components and immunoglobulins.
The product is easily absorbed from the digestive tract, the plasma T1 / 2 of 190 minutes, and tissue T1 / 2 to 3 days, or intramuscular injection of dexamethasone sodium phosphate, respectively for 1 hour and 8 hours of blood after dexamethasone acetate peak concentration. The product is plasma protein binding rate than other low corticosteroids, anti-inflammatory activity of the product is equivalent to 0.75mg 5mg prednisolone.

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