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Pharmacology and Toxicology of Norfloxacin

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-05-27

Norfloxacin (Norfloxacin, also known as Noroxin, Fulgram), alias: alcohol luo, Norfloxacin, buster. Its chemical called 1 - ethyl - 6 - hydrogen fluoride - 1, 4-2-4 - oxygen generation - 7 - (1 - piperazine) - 3 - quinoline carboxylic acid. This product is a third generation quinolone antibacterial, hinder the DNA of pathogenic bacteria in the digestive tract, the effect of rotating enzyme (DNA Gyrase) inhibiting bacterial DNA replication, the bacteria have inhibition. Is commonly used for the treatment of enteritis diarrhea. But the drug have a delay effect on bone formation of minors, will affect the development. Therefore, prohibit minors.

 

The goods Norfloxacin is fluoroquinolone antibiotic, antibacterial effect, especially for aerobic gram-negative bacilli high antibacterial activity, good antibacterial effect in vitro on the following bacteria: most of enterobacteriaceae bacteria, including citron acid bacteria produce gas, sewer, e. coli, enterobacter, e. coli, e. coli, klebsiella bacteria genera, deformation bacteria genera, salmonella, shigella, vibrio genera, yell, bacteria, etc. Norfloxacin to multi-resistant bacteria also has antibacterial activity in vitro. Drug resistance to penicillin gonorrhea neisseria bacterium, haemophilus influenzae and catarrh (also have good antibacterial effect. Norfloxacin as fungicide, by acting on A subunit, bacterial DNA spiral enzyme inhibition of DNA synthesis and replication and killing bacteria.

        

 

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