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Pharmacology and Toxicology of Tobramycin

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-06-04



Indications

The goods suitable for pseudomonas aeruginosa, proteus (indole masculine and feminine), escherichia coli, klebsiella bacteria genera, e. coli, Mr Charest bacteria and staphylococcus (including with methicillin-resistant strains resistant to penicillin G) caused by neonatal sepsis, sepsis, infection of the central nervous system (meningitis), urogenital infection, pulmonary infection, biliary infection, abdominal cavity infection (and peritonitis), bone infection, skin and soft tissue infections (including burns), acute and chronic otitis media, sinusitis, etc. When the goods used for pseudomonas aeruginosa meningitis or ventricle inflammation can intrathecal injection drug delivery at the same time; When used in bronchus and lung infection can dissolve gas suction at the same time the goods as adjuvant therapy. Tobramycin for most group D streptococcus infection is invalid. Used for eye conjunctivitis, keratitis and other bacterial infections, especially of gentamicin resistant gram-negative bacteria stalk infection, such as serious pseudomonas aeruginosa infection effectively.

Pharmacology and Toxicology

Tobramycin can join in the 30 s and 50 s of the connection position, the formation of block 70 s complex, which mRNA cannot be translated into protein, leading to cell death. Of gram-negative bacteria such as pseudomonas aeruginosa, escherichia coli, klebsiella white coli, e. coli, proteus, citrate bacillus effectively. Clinical main used for serious infections caused by sensitive bacteria, such as gram-negative bacteria especially pseudomonas aeruginosa, escherichia coli and klebsiella pneumoniae caused by burn infection, sepsis, infection of the respiratory system, urinary system infection, gallbladder, biliary infection and serious soft tissue infection.

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