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Pharmacology and Toxicology of Valacyclovir Hydrochloride

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-06-13



 

Valacyclovir Hydrochloride is a precursor of acyclovir drug absorption after oral quickly and quickly into acyclovir in the body, the antiviral effect of acyclovir, acyclovir after herpes infection cell, nuclear yesterday competition with DNA virus thymidine kinase kinase or cells, drug is phosphorylated into 3 phosphoric acid activation type acyclic bird ever cool, as the virus replication of the substrate competition with three phosphate solid guanine viral DNA polymerase, thus inhibiting the virus DNA synthesis, showed that the antiviral effect. This product in the body's antiviral activity is better than that of acyclovir, for the treatment of herpes simplex virus type I and type II index is higher than acyclovir 42.91 and 30.13% respectively 0 for varicella zoster virus also has high curative effect, low toxicity to mammalian host cells. Rats and mice to the LD50 were 4.4 g/kg and 1.51 g/kg o due to the product in the body quickly into acyclovir, its metabolites in the body without accumulation phenomenon. In various stages of the long-term toxicity test, the product with acyclovir has the same security.

 

    


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