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Pharmacology of Nevirapine

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-04-29

Nevirapine is HIV - 1 non-nuclear Nucleoside Reverse Transcriptase inhibitors (Non - Nucleoside Reverse Transcriptase Inhibitor, NNRTI). Nevirapine direct connection with HIV - 1 reverse transcriptase and by making the enzyme catalytic side rupture to block the RNA and DNA dependent on DNA polymerase activity.

Pharmacology and Toxicology

In the carcinogenicity study, nevirapine increase mice (dose of 750 mg/kg/day) and rats (dose up to 35 mg/kg/day) the incidence of liver tumors. However, these findings probably with nevirapine is a strong liver enzyme inducers, but won't produce genetic toxicity.

In vitro and in vivo in the following a series of genetic toxicology analysis, no nevirapine showed a genetic mutation or mutagenic activity. These tests include: determination of microbial gene mutation (Ames: samana strains and e. coli), mammalian cell gene mutation identification (CHO/HGPRT), oral drugs after using Chinese hamster ovary cell line cell genetics determined and mouse bone marrow micronucleus appraisal methods. In reproductive toxicity study, data suggest, nevirapine in females in the area under the curve to measure dose reaches full identity cloth, its fertility. The dose and the recommended dose of this drug is used in the human body.

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