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Pharmacology of Piroxicam

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-05-19


(1) The pharmacodynamics of Piroxicam has analgesic, anti-inflammatory and antipyretic effects. This product by inhibiting cyclooxygenase reduce tissue local prostaglandin synthesis and inhibiting leukocyte chemotaxis and lysosomal enzyme release and pharmacological effect. Treatment of arthritis pain, swelling and other efficacy and indomethacin, aspirin, naproxen is similar. But due to the product needed for inhibiting cyclooxygenase - 2 concentration higher than that of inhibiting cyclooxygenase 1 concentration, so the adverse reaction of gastrointestinal tract.

 

(2) The pharmacokinetic: good oral absorption. Food can decrease the absorption rate, but does not affect the total absorption. Plasma protein conjugation rate above 90%. Hepatic metabolism. Half-life is on average 50 hours (30 ~ 86 hours), renal insufficiency in patients with extended half-life. Due to a longer half-life, a drug can maintain 24-hour blood concentrations of relatively stable, multiple dosing is easy to accumulate. A medication 20 mg, 3 ~ 5 hours blood drug concentration to spike, the blood medicine effective concentration is 1.5 ~ 2 mu g/ml. Stable blood drug concentration at the beginning of 7 ~ 12 science can achieve after treatment. Since renal excretion, 66% to 33% since the feces excretion, contains < 5% for prototype.

 

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