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Pharmacology of Vancomycin Hydrochloride

  • Author:Ray Dean
  • Source:www.oceanchinachem
  • Release on :2016-05-03

Vancomycin hydrochloride, as narrow spectrum antibiotics effective only Gram-positive bacteria, such as Streptococcus pneumoniae and enterococci, etc. are sensitive to resistant Staphylococcus aureus is particularly sensitive to this product. Its mechanism of action is inhibition of bacterial cell wall synthesis, and it is mainly the bacterial cell wall binding, leaving some amino acids can not enter the cell wall glycopeptides. Clinical mainly for serious infections caused by penicillin-resistant Staphylococcus aureus, such as pneumonia, endocarditis and sepsis, infection and sepsis caused by hemolytic streptococcus also has a good effect.

Mechanism Vancomycin is a glycopeptide antibiotic, vancomycin hydrochloride as the hydrochloride salt. The mechanism is sensitive to high affinity binding to bacterial cell wall peptidoglycan precursor alanyl alanine terminus, blocking peptide glycan polymer constituting the synthetic bacterial cell wall, cell wall resulting in defects and kill bacteria. In addition, it is also possible to change the permeability of the bacterial cell membrane, and selectively inhibit the synthesis of RNA. The effect of the drug is characterized by Gram-positive bacteria have a strong bactericidal effect; oral administration for the treatment of Clostridium difficile pseudomembranous colitis has a good effect.

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