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Physical and chemical properties of Enrofloxacin

  • Author:Hubei Ocean Biotech Co,.LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-05-10
 
Enrofloxacin (Enrofloxacin), also known as ex-fluoro Gwilym acid, are fluorine quinolones (Fluoroquinolones) of synthetic antibacterial agent as a slightly yellow or light yellow crystalline powder, bitter taste, insoluble in water, soluble in sodium hydroxide solution, methane, methanol and other organic solvents and cyanide. 

Pharmacokinetics
Absorption of oral and intramuscular rapidly and more completely, 0.5--2 hour plasma degrees reached a peak. In addition to the central nervous system, almost all of the drug concentration in tissue were higher than the plasma, which is conducive to systemic infection and deep tissue infections. This product by renal and non-renal elimination of the way, about 15% - 50% of the prototype drug excreted through the urine. Metabolism in animals is mainly off-ethyl become ciprofloxacin. 

Pharmacological effects
This product is a broad-spectrum bactericidal drugs have effects on mycoplasma. Escherichia coli, Klebsiella, Salmonella, Proteus, Pseudomonas aeruginosa, Haemophilus, Pasteurella multocida, Pasteurella hemolytic, Staphylococcus aureus, Streptococcus and others have bactericidal effects. 

Enrofloxacin can be used as animal drugs, the long half-life in animals, there are well-organized distribution, belonging to broad-spectrum antibacterial agent for Gram-positive and Gram-negative bacteria and mycoplasma has antibacterial effects, has It is used to control the breeding of fish disease and E. coli disease Vibrio diseases. 

This product is the third generation of synthetic quinolone antibacterial drugs, also known as ethyl ciprofloxacin, October 4, 1996 approved by the FDA for the livestock and aquaculture dedicated quinolones. With the bacterial DNA gyrase subunit A binding, thus inhibiting the enzyme cutting and connectivity features to prevent the bacterial DNA replication, and showed antibacterial effect. With broad-spectrum antimicrobial activity, has strong permeability, the product of Gram-negative bacteria have a strong killing effect on gram-positive bacteria have good antibacterial activity, good oral absorption, high plasma concentrations and stability, can be widely distributed in the organization, and its metabolites as ciprofloxacin, there is still a strong antibacterial effect. Almost all aquatic animal pathogens are strong antibacterial activity. Serious infections caused by resistant pathogens cause effective, with no cross-resistance to other antibiotics.

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