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Precautions Of Cyclosporine A

  • Author:Hubei Ocean Biotech Co,.LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-04-25
Cyclosporine A consists of 11 amino acids, belonging potent immunosuppressant. Mainly used in clinical liver, kidney and heart transplant anti-rejection reactions can also be used with adrenal corticosteroids, treatment of autoimmune diseases.
Cyclosporine A (cyclosprine, CyA) is a cyclic polypeptide consisting of 11 amino acids, is a soil active metabolite of the fungi. In 1978 the UK for the first time CyA used in clinical transplantation, and thereafter CyA for liver, heart, lung, pancreas, bone marrow transplants, have achieved satisfactory results, significantly improved patient survival. cyclosporin a into China in 1984, forming a "+ azathioprine cyclosporine a + hormone" triple immunosuppressive regimen, significantly improved graft survival, but also to the incidence of acute rejection after transplantation reaction .CyA dropped significantly as a potent immunosuppressant, research in recent years more and more people it found it can also be used to treat autoimmune diseases, blood diseases and anti-parasitic disease
Precautions
1. Renal toxicity: glomerular thrombosis, tubular blocked, proteinuria, urinary tube.
2. Liver toxicity: hypoproteinemia, hyperbilirubinemia, elevated serum transaminases.
3. nervous system: spinal motion syndrome, cerebellum-like syndrome and mental disorders, tremor, sensory abnormalities.
4. Gastrointestinal: anorexia, nausea, vomiting.
5. Although there is no contraindication for a bone marrow transplant, but there are adverse reactions.
6. hypertension, hirsutism. Intravenous administration even visible chest, facial redness, difficulty breathing, wheezing and heart palpitations and other allergic reactions. The event should be discontinued immediately, serious oxygen and intravenous epinephrine rescue.
7.1 years of age should not use children.

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