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Stability of Pantoprazole Sodium

  • Author:Ray Dean
  • Source:www.oceanchinachem
  • Release on :2016-04-21

Pantoprazole Sodium is a medicare non-prescription drug. Suitable for the treatment of acute upper gastrointestinal bleeding duodenal ulcer, acute gastric mucosal lesions of gastric ulcer, gastric ulcer and other compound. Commonly used are tablets, capsules and injections. Of this allergy, pregnant women and lactating women disabled. It can also be used for long term treatment of Zollinger-Ellison syndrome.

Determination of content changes within 4h injection with pantoprazole sodium and four kinds of infusions after using high performance liquid chromatography, and observe the appearance of the solution; also investigated potassium, magnesium, calcium and pH changes in the injection of pantoprazole Effects of sodium azole stability. Results: pantoprazole sodium for injection in four common infusion and potassium, magnesium, calcium ions in the aqueous solution within 4h their content, appearance, pH value, the maximum UV absorption wavelength were no significant changes. PH value lower than 7.0 pantoprazole sodium extremely unstable; pH value of 7.0, the color change may be yellow, but the content is not changed significantly; solution pH values above 8.0 Torr Pan omeprazole sodium stable in 4 hours.

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