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Usages of Probenecid

  • Author:Kathy
  • Source:www.oceanchinachem.com
  • Release on :2016-06-13

Usages of Probenecid

Probenecid mainly use in the interphase and chronic gout attacks used to control the high uric acid hematic disease, applicable to the increased blood uric acid and renal function is good, uric acid eduction of the few patients every day, also for thiazide diuretics or have gout caused by dangerous high uric acid hematic disease treatment, is generally not as an aid in the treatment of high uric acid hematic disease caused by cancer treatment. Because this product can inhibit the penicillin and cephalosporin class from the eduction in renal tubules secrete, increase their blood drug concentration, therefore, can be used as some need to maintain long-term high concentration of penicillin and cephalosporin blood levels of adjuvant treatment of the disease, such as subacute infective endocarditis, gonorrhea, etc.

 

Efficacy

 

1. Inhibition of urate in proximal renal tubular active resorption, increases the excretion of uric acid salt and reduce the concentration of blood uric acid salt. Can alleviate or prevent the generation of urate nodules, reduce joint damage, can also promote has formed the uric acid salt dissolving. The anti-inflammatory and analgesic action. For the treatment of chronic gout.


2. Can be competitive inhibition of weak organic acid (such as penicillin, the first cephalosporins) in renal tubular secretion, so it can increase the blood levels of antibiotics and to extend the time of their functions.

 

    

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