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What is Colistin sulfate

  • Author:Hubei Ocean Biotech Co,.LTd
  • Source:www.oceanchinachem.com
  • Release on :2016-04-25
Colistin sulfate, also known as colistin sulfate, Kristin (Colistin), polymyxin E (Polymyxin E), and other enemy elements, white or nearly white powder, odorless, bitter, hygroscopic, soluble in water, slightly soluble in methanol, ethanol, practically insoluble in acetone and ether, water-soluble free base. Stable in PH3-7.5 range. Colistin sulfate produced by the Bacillus polymyxa, Gram-negative bacteria have a strong antibacterial effect, for the treatment of intestinal diseases caused by Gram-negative bacteria, used as feed additives, and there is significant growth-promoting effect. And sulfadiazine combination effect is better.
Mainly Gram-negative bacteria have a strong antibacterial effect, susceptible Pseudomonas aeruginosa, Escherichia coli, Enterobacter, Klebsiella, Salmonella, Shigella, Vibrio and Pasteurella Wait. The Proteus, Brucella, Serratia, and all gram-positive bacteria are resistant to the chemicals. Phosphate (a negative charge) polymyxin class of fungicides slow effect, a major role in the bacterial cell membrane, when in contact with susceptible strains, the chemical structure of a free amino group (positive charge) and bacterial cell membrane phospholipid binding so that an increase in membrane permeability, resulting in important intracellular substances such as amino acids, purine, pyrimidine, K +, etc. leakage. It can also affect the function of nuclear matter and the ribosome. Bacteria on the goods easy to produce drug resistance, and no cross-resistance with other antibiotics phenomenon, but there is complete cross-resistance between polymyxin) and B.
This product is rarely absorbed orally, poor distribution of the drug in the body after absorption of short duration. After oral administration of bile 8h addition, other organizations only trace all organizations no residue after 16h. After injection of wide distribution, 0.5-1h reached a peak in major organizations, but difficult to penetrate to the chest, and foci within the joint cavity, it is difficult to build into the cerebrospinal fluid. 6h after removing blood, trachea, salivary gland, kidney, urine outside can not be detected, 24h after addition to the trachea, kidney, urine can not be detected outside. Low protein binding drugs. Primarily by renal excretion, renal insufficiency easy to accumulate in the body.

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