Adverse Reactions Simvastatin

  • Author:Kathy
  • Release on :2016-06-01

Simvastatin is generally well tolerated, with most adverse reactions mild and transient. In controlled clinical trials only less than 2% of the patients due to the adverse effects of simvastatin drug withdrawal.


In the control group in clinical trials, adverse reactions (divided into may, suspicious, or certainly) the incidence of associated with the drug is greater than or equal to 1% of are: abdominal pain, constipation, gastric bowel to bilge gas. Incidence was 0.5% ~ 0.5% of the adverse reactions are fatigue, weakness, headache. Found it very rare reports of myopathy.


The following reports of adverse reactions occurred in the absence of control group in clinical trials or of applications, such as nausea, diarrhea, skin rash, indigestion, itching, hair loss, dizziness, muscle cramps, muscle pain, pancreatitis, paresthesia, peripheral neuropathy, vomiting and anemia; Rhabdomyolysis and hepatitis/jaundice rare occurrence.


Include one or more of the following characteristics of obvious allergic reaction syndrome rarely reported, such as angioneurotic oedema, lupus syndrome, rheumatoid multiple myalgia, vasculitis, thrombocytopenia, increased eosinophils, blood sedimentation (ESR) increased, arthritis, joint pain, urticaria, photosensitivity, fever, flush, dyspnea and discomfort.


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