Antitubercular Agent of Isoniazid

  • Author:Ray Dean
  • Release on :2017-04-14

Isoniazid, a colorless crystal, or white to white crystalline powder; odorless, slightly sweet taste bitter; case of light gradually metamorphic. This product is soluble in water, slightly soluble in ethanol, very little in ether. Melting point This product has a melting point of 170 to 173 ° C. Isoniazid was invented in 1952, the invention of isoniazid to make a fundamental change in the treatment of tuberculosis. In this nearly 50 years of use history, although some patients infected with TB has been resistant, but the vast majority of doctors still think it is an indispensable treatment of tuberculosis medicine. And rifampicin (rifampicin), ethambutol (ethambutol), streptomycin (sterptomycin) and pyrazinamide (pyrazinamide) with the first line of anti-TB drugs.


The development of next-generation anti-tuberculosis drugs is underway. Clinical trials of fluoroquinolones antibiotics, as well as capreomycin, cycloserine (oxazolamycin), linezolid such as antibiotics. These drugs are shown to be lethal to Mycobacterium tuberculosis with multiple drug resistance (MDR-TB). The vast majority of doctors still believe that before the emergence of new cure, isoniazid is an indispensable treatment of tuberculosis. For drug-sensitive tuberculosis patients, isoniazid is usually the first doctor to open the drug, many times this is the fastest to save the patient's life choice.


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