Interaction with ketoconazole

  • Author:Hubei Ocean Biotech Co.,LTd
  • Release on :2016-04-18

1. The goods with astemizole, not that dean. Share due to the inhibition of cytochrome P - 450 metabolism, causing astemizole, not that dean or paracel shall be elevated blood drug concentration, which can lead to heart rhythm disorders and even death.

        2. The goods with alcohol and liver toxicity medicines, can make the increased hepatotoxicity of producing. Long-term therapy or liver disease patients with original application of this two kinds of drugs should be given strict monitoring, and should avoid alcohol.

        3. Coumarin anticoagulants, warfarin or indan diketone derivatives and share when the goods can be enhanced, leading to lengthen prothrombin time, therefore, should closely observe the patient monitoring prothrombin time, and dosage should be adjusted.

       4. The goods can make ring higher blood concentrations of spore element, and could make an increased risk of renal toxicity, so only in very strict observation and monitoring of blood drug concentration, to consider the joint application of both classes of drugs.

       5. The goods with acid medicine, anticholinergic drugs, sedatives, histamine H2 receptor antagonist medicine, omeprazole, sucralfate share, can make the goods of the absorption decreased significantly, so share should be avoided. If you want to share, then at least more than 2 hours, respectively.

      6. The goods with rifampin, isoniazid share, blood drug concentration is reduced, which can lead to treatment failure or relapse.

      7. Benzene completed with the goods share, can make the benzene completed due to the slow metabolism, leading to the blood drug concentration increased significantly, at the same time that the goods can be blood drug concentration is reduced, so the two kinds of medicines should closely observe the reaction.

      8. To hydroxyl inosine (didanosine, DDI) contained in the buffer can make the gastrointestinal pH increases, and the goods with acid absorption in the environment is beautiful, so can affect the absorption of the goods at party. When he has to share more than 2 hours.

     9. The goods with amphotericin B antagonist, share the curative effect.

   10. Ketoconazole can affect the metabolism of budesonide, no obvious clinical significance under the recommended dose.