Medical Effects of Benfotiamine

  • Author:Ray Dean
  • Source:www.oceanchinachem
  • Release on :2016-04-27

Benfotiamine is fat-soluble derivative of vitamin B1, in addition to different physical and chemical properties than the water-soluble vitamins B1, except that the structure has an open thiazole ring, a closed loop is formed by in vivo physiological activity acts vitamin B1.

After ingestion, maximum plasma concentration of vitamin B1 and vitamin B1 intake greater than about 5 times the maximum bioavailability of approximately 3.6 times the intake of vitamin B1, vitamin B1 derivative than other fat-soluble . Human and animal studies have shown that, compared with the form of water-soluble vitamins, higher bioavailability and biological activity of benfotiamine. Compared with vitamin B1, plasma, whole blood, red blood cells and tissues, and vitamin B1 peak and total phosphate concentration higher benfotiamine generated, the plasma half-life is longer. In muscle tissue (5 times) and brain (25-fold) relative bioavailability increase is more significant in other tissues such as the liver and kidney, there are 10 to 40 percent increase.

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