Medical Effects of Chloramphenicol

  • Author:Ray Dean
  • Release on :2016-07-21

Chloramphenicol is a broad-spectrum antimicrobial agent. By fat-soluble dispersible into the bacterial cells, a major role in the 50s 70s subunit of bacterial ribosome, inhibiting GGT so hindered the growth of the peptide chain, inhibits the formation of the peptide chain, thereby preventing protein synthesis. High concentrations of highly sensitive goods or bacteria also showed bactericidal effect.


Chloramphenicol on the more general role of gram-negative bacteria Gram-positive bacteria stronger. There susceptible Enterobacteriaceae (such as E. coli, Enterobacter aerogenes, Klebsiella, Salmonella, etc.) and Bacillus anthracis, Streptococcus pneumoniae, Streptococcus, Listeria, Staphylococcus aureus. Chlamydia is also sensitive to the chemicals, Leptospira, Rickettsia. The product of anaerobic bacteria such as Clostridium tetani, Clostridium perfringens, actinomycetes and lactic acid bacteria, Fusobacterium, also a considerable role. But for Pseudomonas aeruginosa, Mycobacterium tuberculosis, viruses, fungi, etc. is not valid.


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