Medical Function Of Teicoplanin

  • Author:Ray Dean
  • Source:www.oceanchinachem
  • Release on :2016-04-21

Teicoplanin, also known as Pacific neomycin, was first discovered in 1975. It is specific to swimming actinomycetes. After fermentation and extraction to give a family of glycopeptide vancomycin antibiotic, antibiotic plurality of chemical structure very similar to a mixture composed of the compound.

On teicoplanin and vancomycin structure is different, the peptide backbone more fatty acid side chains to improve the lipophilic, more easily penetrate tissues and cells. Therefore, in the treatment of teicoplanin showed more than vancomycin advantages:

(1) has a low toxicity, especially significantly lower renal toxicity;

(2) has a much longer half-life than vancomycin, is only injected once a day;

(3) has a more convenient route of administration than vancomycin, can be administered intravenously or intramuscularly.

(4) in vivo antibacterial activity of teicoplanin vancomycin several times, with other antibiotics combined with high safety, and have a long post-antibiotic effect.

Therefore, teicoplanin more conducive to outpatient treatment and patient acceptance.

Teicoplanin and vancomycin have similar antimicrobial spectrum of aerobic and anaerobic Gram-positive bacteria have antibacterial activity. Susceptible Staphylococcus aureus and coagulase-negative staphylococci (including methicillin sensitive and resistant), streptococci, enterococci, mononucleosis Secretary of Lee special bacteria, Micrococcus, JK group and Corynebacterium Gram-positive anaerobic bacteria, which include Clostridium difficile and digestive bacteria.

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