Medical Function of Calcium Folinatc

  • Author:Ray Dean
  • Source:www.oceanchinachem
  • Release on :2016-04-21

Calcium Folinate , also name as Folinic acid, is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan, where it may "rescue" bone marrow and gastrointestinal mucosa cells from methotrexate. No apparent effect is seen on pre-existing methotrexate-induced nephrotoxicity.Folinic acid can be taken as a pill (orally) or injected into a vein (intravenously) or muscle (intramuscularly).


Another application is to improve the efficacy of fluorouracil with fluorouracil. Deoxy-uridine monophosphate (dUMP) required to undergo THF catalyzed bear guanylate synthase (TMPS) in DNA synthesis in turn to the formation of methyl deoxythymidine acid (dTMP). In this case, the need to make dihydrofolate dihydrofolate reductase into THF. The main mechanism of action of fluorouracil after entering the body into a first-fluorouracil deoxynucleotides inhibiting thymidylate synthase (TMPS). During the reaction TMPS with THF, it dumps three form a transition complex. After completion of the reaction is generally complexes decompose, releasing dihydrofolate, TMPS enzymes and dTMP. But after giving the triple composite formation can not be decomposed fluorouracil, enzyme function is inhibited, can not be produced dTMP. The binding of the enzyme and deoxynucleotide fluorouracil proportional to the concentration of THF, THF improve the supply of Fluorouracil can inhibit the action of the enzyme TMPS enhanced.

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