Pharmaceutical Action of Celecoxib

  • Author:Ray Dean
  • Source:www.oceanchinachem
  • Release on :2016-08-11

Celecoxib is a nonsteroidal anti-inflammatory drugs, in animal models observed to have anti-inflammatory, analgesic and antipyretic. This product is the mechanism through inhibition of cyclooxygenase -2 (COX-2) to inhibit prostaglandin production. And therapeutic concentrations in the human body, the product of the isoenzyme cyclooxygenase - -1 (COX-1) had no inhibitory effect. In animal colon tumor models, celecoxib slowed tumor development and progression.


After NSAID overdose response to disease treatment and supportive care. There is no specific antidote. No regard to the removal of hemodialysis celecoxib research data, but because of its high plasma protein binding, excess dialysis therapy may not be effective. When such a large excess of asymptomatic or within 4 hours after overdose the patient, the drug can also be used to induce vomiting, and / or activated carbon (adult 60-100g, children 1-2g / kg), and / or permeability cathartic methods such treatment. Since the protein binding rate, diuresis, alkalinization of urine, hemodialysis or ultrafiltration may be invalid.


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