Pharmaceutical Application of Adenosine

  • Author:Ray Dean
  • Release on :2016-11-17

Adenosine is a compound formed by linking N-9 of adenine and C-1 of D-ribose through a β-glycosidic bond. The phosphate is adenylate. Adenosine is a kind of endogenous nucleoside, which can directly enter the myocardium through the phosphorylation of adenosine, participate in myocardial energy metabolism, but also involved in the expansion of coronary blood vessels, increase blood flow. Adenosine has a physiological effect on the cardiovascular system and many other systems and tissues of the body. Adenosine is an important intermediate for the synthesis of adenosine triphosphate (ATP), adenine, adenosine, and adenosine.


When it is administered intravenously, adenosine causes transient heart block in the atrioventricular (AV) node. This is mediated via the A1 receptor, inhibiting adenylyl cyclase, reducing cAMP and so causing cell hyperpolarization by increasing inward K + flux via inward rectifier K + Inhibiting Ca2 + current.It also causes endothelial-dependent relaxation of smooth muscle as is found inside the artery walls. This causes dilation of the "normal" segments of arteries, ie where the endothelium is not separated from the tunica media by atherosclerotic plaque. Feature allows physicians to use adenosine to test for blockages in the coronary arteries, by exaggerating the difference between the normal and abnormal segments.


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