Pharmaceutical Intermediate of Dextran

  • Author:Ray Dean
  • Release on :2016-09-20
Dextran is a white or off-white amorphous powder, odorless, tasteless. Soluble in water, insoluble in ethanol. Their solution is a colorless, clear liquid or slightly opalescent. By the intestinal membrane Leuconostoc fermentation synthesis of a polymer of glucose polymer, it is currently one of the best plasma substitutes. There are commonly used in clinical molecular dextran, mainly used as plasma substitutes for hemorrhagic shock, traumatic shock and burn shock. Low, small molecule dextran, can improve microcirculation, prevention or elimination of red blood cell aggregation and thrombus formation within blood vessels, also expand blood volume, but the effect of the relatively short molecular dextran; for microcirculation shock caused by a variety, disseminated intravascular coagulation, angina pectoris, acute myocardial infarction and other peripheral vascular diseases.

Blood volume expansion drugs, increased plasma colloid osmotic pressure, increased plasma volume and maintain blood pressure, red blood cells and can prevent platelet aggregation, reduce blood viscosity, so that the role of microcirculation. The product is mainly excreted through the kidneys, the excretion rate and molecular size. When the body of people for one hour, the low, small molecule dextran were discharged from the urine of 30%, 50%, 70%; 60% were discharged after 24 hours, 70%, 80%.

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