Pharmaceutical Raw Material of Famciclovir

  • Author:Ray Dean
  • Release on :2016-12-01

Famciclovir is a 6-deoxy derivative of penciclovir diacylglycerol into the body quickly into penciclovir, penciclovir can be virus-encoded thymidine kinase phosphorylation to OCV monophosphate, and then by the host Phosphorylation into penciclovir triphosphate, triphosphate in the virus-infected cells quickly formed, slow metabolism, causing half-life extension, involved in HBV DNA-p of guanosine triphosphate (Pgtp) competition, and into the DNA, the role of In the DNA synthesis and extension of the initial step, inhibition of DNA synthesis, on varicella - zoster virus, herpes simplex virus type 1 and type 2 and HBV have a strong inhibitory effect.


Effect of oral famciclovir on replication of duck hepatitis B virus in duck embryo liver tissue and non - liver tissue cells. In the same year Boker, etc. for the first time with prostaglandin E plus famciclovir treatment of 1 case of liver transplantation in patients with severe hepatitis B after the success. After treatment, liver function recovery, viral replication was inhibited, HBV DNA and HBeAg were turned negative, only HBsAg positive, liver histological inflammation improved,


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