Pharmaceutical Raw Material of Palonosetron Hydrochloride

  • Author:Ray Dean
  • Release on :2016-12-13

Palonosetron Hydrochloride is a new high-selective, high-affinity 5-HT3 receptor antagonist that blocks nausea and vomiting, and blocks pre-synaptic 5-HT in vomiting reflex central peripheral neurons. Receptors, and directly affects central nervous system 5-HT. Receptor excitatory impulses through the vagal transmission of the role of the posterior region, blocking vaginal nerve endings in the intestine to prevent the signal transmission to the 5-HT. Receptor triggering area, reduce the incidence of nausea and vomiting. Clinically for the treatment of moderate to severe emetic chemotherapy drugs caused by acute, delayed nausea and vomiting.


Clinical studies have shown that palonosetron can be safely used with corticosteroids, analgesics, antiemetics, antispasmodics and anticholinergic drugs. A mouse tumor model study showed that palonosetron did not inhibit the anticancer activity of the five chemotherapeutic drugs studied (cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C).


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