Pharmacokinetic Characteristics of Cilnidipine

  • Author:Kathy
  • Release on :2016-05-26

Recent research shows healthy adult male single respectively take Cilnidipine 5 mg entered, 10 mg, 20 mg, blood drug concentration increased with the increase of the dose increased, max are between 1.8 to 2.2 hours, the plasma half-life between 2.1 to 2.5 hours, because of its high lipotropy molecular characteristics, part of the drug store in the lipid bilayer, slower with the cell membrane dissociation, slow release, the effective blood drug concentration up to 23 hours time. For seven days, prototype drug concentration in plasma (23 hours after the treatment of plasma concentration determination results) after dosing 4 and 7, no obvious change, prompted the drug without chemicals. Diet and renal function were not affect blood drug concentration in the body entered. Drugs through the upper small intestine absorption, mainly in the form of metabolites via the urine. Plasma proteins in the body combined rate of 99.3%, dialysis does not affect the blood drug concentration.

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